**FPGEE Self Assessment
**

**I. FPGEE Pharmaceutical, management, pharmacokinetic calculations practice questions.**

- A drug has an elimination half life of 4 hours and its apparent volume of distribution is 100 ml /kg. What is the total body renal clearance of this drug in a 65-kg male in terms of L/hr?
- Estimate the plasma concentration of a drug when 50 mg is given by IV bolus to a 130 lb patient if her volume of distribution is 1.2 L / kg.
- Determine the half-life of furosemide if it appears to be eliminated from the body at a rate constant of 56% / hr. (assume that first order kinetics occurs)
- How many mg of aminophylline should be given as a loading dose if a theophylline plasma level of 10 mg / L is desired in a 55 year old male patient weighing 70 kg? His volume of distribution (Vd) has been calculated to be 35 L assume aminophylline consists of 85% theophylline and 15% ethylenediamine and what is the maintenance dose appropriate if the clearance is estimated to be 0.35 ml/min./kg?
- Given: 31, 62, 44, 58, 75, 86, 55, 90. Calculate the mean
- Given: 31, 62, 44, 58, 75, 86, 55, 90. Calculate the median
- A patient receives 250 ml of normal saline in five hours. What is the hourly rate?
- A patient is to receive 1.5 L of heparinized saline in one-hour infusion. What is the flow rate in ml / minute?
- An order states that 100,000 units of penicillin is to be added to a 2 L bag of saline and infused in 5 hours. Your infusion set is labeled 10 gtts / mL. What is the flow rate in gtt / min?
- An IV is running at a rate of 40 gtts / min. The infusion apparatus is a macrodip apparatus (10 gtt / mL). What is the flow rate in mL / hr?
- What is the ph of a solution having a ratio of ionized to unionized species of drugs of 1X10 to the negative 5 (pKa = 7)?
- How much Sodium bicarbonate powder is required to prepare 250 ml of 0.10 N solution of NaHC03 (MW is 84 gm/mole)?

- How many ml of concentrated HCl acid are required to prepare 400 ml of 0.06 N acid solution? (MW= 36.5 g/mole, purity of HCl = 37% w/w, density =1.2 g/ml)
- How many mEq of Na are present in 0.9% 500 ml NS solution (Na =23 Cl = 35.5)
- How many mEq of Na are present in 50% 175 ml of NaHCO3 solution. (MW= 84 g/mole)
- What is the half life of a drug that has a rate of constant of 0.032 days (1
^{st}order kinetic) - How long will it take to decompose digoxin to one half of its original concentration? (Rate of constant k = 0.043 min.)
- What is the half-life of a drug that is in second order if the initial concentration of the drug was 0.005 M (rate of constant = 5 L/mole min.)
- What is the rate of infusion of phenytoin in a patient that requires steady state plasma concentration of 40 meq/ml? the elimination half life of phenytoin is 8 hrs. and apparent volume of distribution is 25 L?
- The rate of infusion of rocephin is 20 mg/hr. How long will take to infuse 500 mg/100 ml rocephine?
- The ratio of ionized to unionized acetic acid in a solution is 100:1. What is the pH of a solution having pKa 7.5?
- What is the ratio of ionized to unionized drugs at pH = 7? (pKa = 9)
- What is the pH of a buffer solution prepared with 0.05 M disodium phosphate and 0.05 M sodium acid phosphate (pKa = 7.21)?
- What is the co-pay for a prescription of Amoxicillin 250 mg #30 if the co-pay is 20% of the usual and customary price for the prescription and the usual and customary price for Amoxicillin 250 mg #30 is $8.49?
- What is the co-pay for a prescription of Motrin 400 mg #20 if the brand name is specified by the patient, the co-pay amount is $5, the cost of Motrin 400 mg #20 is $3.74 and the cost of ibuprofen 400 mg #20 is $2.22?
- How much will a pharmacy be reimbursed for a prescription if the third-party contracts states the pharmacy will be reimbursed at 85% of AWP + $2.50 dispensing fee, and if the AWP for the prescription is $23.65?
- Calculate the amount the patient would pay if the patient qualifies for a 5% discount and the retail price is $74.27?

28. If prescription prices are determined using the ff: formula: AWP (Average Wholesale Price) + professional fee = Selling price of prescription and the professional fee is determined using the ff: chart:

AWP Professional Fee:

Less than $20.00 $4.00

$20.01- $50.00 $5.00

$50.01 and higher $6.00

and the AWP for 30 capsules of amoxicillin 250 mg is $3.50, what will be the retail price of the prescription?

Since the AWP for the prescription is less than $20.00, the professional fee is $4.00. Using the Formula: AWP = Professional fee = Selling price

29. A prescription for Amoxicillin 250 mg #30 has a usual and customary price of $8.49. The acquisition cost of amoxicillin 250 mg # 30 is $2.02. What is the gross profit?

30. How Health Insurance Deductibles are used and calculated?